Tissue can be fresh (in metal free royal blue), paraffin-embedded, or dried. Also acceptable: Formalin-fixed.
Unacceptable Conditions
Specimens less than 0.25 mg (dry weight). Specimens stored or shipped in saline.
Collection Comments
Transport at least a 1 cm long specimen obtained with an 18 gauge needle (Minimum 0.25 mg dry weight).. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens should be stored and transported in a metal-free container such as a royal blue (no additive) or a metal free aliquot. Age is required in order to calculate iron index. Please enter patient age in order comment.
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens should be stored and transported in a metal-free container such as a royal blue (no additive).
Age is required on test request form in order to calculate iron index.
Ordering Recommendations
Useful in confirming hepatic iron overload, particularly in individuals with hemochromatosis and no common HFE mutations. Initial approach to diagnosis for hemochromatosis should include Iron and Iron Binding Capacity (0020420) (NOTE: test includes serumtransferrin saturation) and Ferritin (0070065). http://ltd.aruplab.com/Tests/Pub/0028250
A Hepatic Iron Index (HII) is not calculated for patients less than 14 years. An HII less than 1.0 is consistent with normal iron accumulation. An HII 1.0 through 1.9 is consistent with mild iron accumulation such as in heterozygous hemochromatosis or alcoholic liver disease. An HII greater than 1.9 is consistent with iron overload such as in homozygous hemochromatosis, porphyria cutanea tarda, and cirrhotic liver disease. The HII will decrease with chelation, chronic blood loss, or phlebotomy.
Tissue can be fresh (in metal free royal blue), paraffin-embedded, or dried. Also acceptable: Formalin-fixed.
Unacceptable Conditions
Specimens less than 0.25 mg (dry weight). Specimens stored or shipped in saline.
Collection Comments
Transport at least a 1 cm long specimen obtained with an 18 gauge needle (Minimum 0.25 mg dry weight).. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens should be stored and transported in a metal-free container such as a royal blue (no additive) or a metal free aliquot. Age is required in order to calculate iron index. Please enter patient age in order comment.
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens should be stored and transported in a metal-free container such as a royal blue (no additive).
Age is required on test request form in order to calculate iron index.
Ordering
Ordering Recommendations
Useful in confirming hepatic iron overload, particularly in individuals with hemochromatosis and no common HFE mutations. Initial approach to diagnosis for hemochromatosis should include Iron and Iron Binding Capacity (0020420) (NOTE: test includes serumtransferrin saturation) and Ferritin (0070065). http://ltd.aruplab.com/Tests/Pub/0028250
A Hepatic Iron Index (HII) is not calculated for patients less than 14 years. An HII less than 1.0 is consistent with normal iron accumulation. An HII 1.0 through 1.9 is consistent with mild iron accumulation such as in heterozygous hemochromatosis or alcoholic liver disease. An HII greater than 1.9 is consistent with iron overload such as in homozygous hemochromatosis, porphyria cutanea tarda, and cirrhotic liver disease. The HII will decrease with chelation, chronic blood loss, or phlebotomy.
