Specimen types other than CSF. Contaminated, heat-inactivated or hemolyzed specimens; Bloody CSF (Per ARUP medical director, we cannot complete testing on CSF specimens which exhibit the presence of blood. Blood in CSF indicates gross serum contamination which can potentially introduce serum antibodies into the CSF.)
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Storage/Transport Temperature
Refrigerated CSF
Stability (from collection to initiation)
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
Remarks
Indicate source on test request form.
Ordering Recommendations
For suspected and/or active herpes simplex virus (HSV) infection, molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)). If pursuing antibody testing, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (0050379) and Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (0050359). If acute HSV infection is suspected, molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).
Performed
Sunday - Saturday
Methodology
Chemiluminescence Immunoassay
Reported
2 days
Performing Lab
Send Outs
Referral Lab
ARUP Laboratories
Synonyms
5617
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF
ARUP 0050394
Interpretive Data
The detection of antibodies to herpes simplex virus in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94% of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.
NOTE: Not generally recommended. If acute and/or active herpes simplex virus (HSV) infection is suspected, molecular testing is preferred.
Specimen types other than CSF. Contaminated, heat-inactivated or hemolyzed specimens; Bloody CSF (Per ARUP medical director, we cannot complete testing on CSF specimens which exhibit the presence of blood. Blood in CSF indicates gross serum contamination which can potentially introduce serum antibodies into the CSF.)
Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Storage/Transport Temperature
Refrigerated CSF
Stability (from collection to initiation)
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
Remarks
Indicate source on test request form.
Ordering
Ordering Recommendations
For suspected and/or active herpes simplex virus (HSV) infection, molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)). If pursuing antibody testing, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (0050379) and Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (0050359). If acute HSV infection is suspected, molecular testing is preferred (refer to Herpes Simplex Virus by PCR (0060041)).
Performed
Sunday - Saturday
Methodology
Chemiluminescence Immunoassay
Reported
2 days
Performing Lab
Send Outs
Referral Lab
ARUP Laboratories
Synonyms
5617
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF
ARUP 0050394
Result Interpretation
Interpretive Data
The detection of antibodies to herpes simplex virus in CSF may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier.
Fourfold or greater rise in CSF antibodies to herpes on specimens at least 4 weeks apart are found in 74-94% of patients with herpes encephalitis. Specificity of the test based on a single CSF testing is not established. Presently PCR is the primary means of establishing a diagnosis of herpes encephalitis.
NOTE: Not generally recommended. If acute and/or active herpes simplex virus (HSV) infection is suspected, molecular testing is preferred.
