Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain. Samples collected on wooden sticks or applicator sticks.
Collection Comments
Liver tissue obtained with an 18 gauge needle. Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive). http://ltd.aruplab.com/Tests/Pub/0020694
Specimen Preparation
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).
May be useful when related serum or urine assessments are inconclusive. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.
http://ltd.aruplab.com/Tests/Pub/0020694
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.
Clinical Interpretation
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity inhepatic copper distribution.
Interpretation and Reference Range
CPT Codes
82525
Test Code (Outreach Synonym)
10448
Catalog Code
429812697
Collection
Collect
Tissue, Royal Blue (No additive) - Red band
Preferred Draw Volume
2 cm
Minimum Draw Volume
1 cm
Other Acceptable Containers
Fresh, paraffin-embedded or dried tissue
Unacceptable Conditions
Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain. Samples collected on wooden sticks or applicator sticks.
Collection Comments
Liver tissue obtained with an 18 gauge needle. Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive). http://ltd.aruplab.com/Tests/Pub/0020694
Specimen Preparation
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive).
May be useful when related serum or urine assessments are inconclusive. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.
http://ltd.aruplab.com/Tests/Pub/0020694
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.
Clinical Interpretation
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity inhepatic copper distribution.
Interpretation and Reference Range
