Horizon is a carrier screen that evaluates a patient's carrier status for up to 274 autosomal-recessive and X-linked genetic conditions. There are five (5) different panels that check between 4 and 274 genetic conditions.
This test requires prior authorization (PA) and should be placed as a future order in the outpatient setting. If unable to obtain PA, please have patient sign a financial waiver.
Synonyms
Natera
Horizon
LAB123143
Collect
This is a kit collection. Follow kit instructions for sample collection. (Two 6 mL K2 EDTA - Lavender BCT blood tubes needed).
If collecting samples for both Panorama and Horizon, draw two 10 mL Tiger Top tubes (Streck tubes) and one 6 mL K2 EDTA tube (Combo kit available from ARL).
Storage/Transport Temperature
CRITICAL ROOM TEMPERATURE
Unacceptable Conditions
Refrigerated and frozen samples.
Reference Interval
See interpretive report.
CPT Codes
CPT Codes for reference:
CPT CODE LIST
Test description
AMA CPT Code
Qty
Description
Panorama
81420
1
Fetal chromosomal aneuploidy (eg, trisomy 21, monosomy X) genomic sequence analysis panel, circulating cell-free fetal DNA in maternal blood
Panorama (Trisomy 21, 18 & 13)
81507
1
Fetal chromosomal aneuploidy (eg, trisomy 21, monosomy X) genomic sequence analysis panel, circulating cell-free fetal DNA in maternal blood, must include analysis of chromosomes 13, 18, and 21
Pannorama Microdeletions
81422
1
Fetal chromosomal microdeletion(s) genomic sequence analysis (eg, DiGeorge syndrome, Cri-du-chat syndrome), circulating cell-free fetal DNA in maternal blood
Horizon 4
81220
1
CFTR gene analysis; common variants
81243
1
Fragile X
81329
1
Spinal Muscular Atrophy
81161
1
DMD - Muscular Dystrophy
81408
1
DMD - Muscular Dystrophy
Horizon 27
81200
1
Canavan Disease (ASPA)
81209
1
Bloom Syndrome (BLM)
81220
1
Cystic Fibrosis (CFTR)
81242
1
FANCC
81243
1
Fragile X
81250
1
G6PC
81251
1
Gaucher Disease (GBA)
81255
1
Tay-Sachs Enzyme (HEXA)
81257
1
Alpha Thalassemia
81260
1
Familial Dysautomomia (IKBKAP)
81290
1
Mucolipidosis Type IV (MCOLN1)
81329
1
Spinal Muscular Atrophy
81330
1
Niemann-Pick Disease (SMPD1)
81361
1
HBB
81400
2
Spinal Muscular Atrophy
81401
1
Spinal Muscular Atrophy
81404
1
Usher Syndrome, Type 3
81405
1
X linked Severe Combined Immunodeficiency
81161
1
DMD - Muscular Dystrophy
81406
2
Maple Syrup Urine Disease, Type 1B - Full Gene Sequence
81408
2
DMD - Muscular Dystrophy
Horizon 106
81412
1
Ashkenazi Jewish assoc dis
Horizon 274
81200
1
Canavan Disease (ASPA)
81209
1
Bloom Syndrome (BLM)
81220
1
Cystic Fibrosis (CFTR)
81251
1
Gaucher Disease (GBA)
81205
1
BCKDHB
81238
1
F9
81242
1
FANCC
81243
1
Fragile X
81250
1
G6PC
81254
1
GJB6
81329
1
Spinal Muscular Atrophy
81361
1
HBB
81402
1
MPL
81403
1
KCNJ11
81161
1
DMD - Muscular Dystrophy
81255
1
Tay-Sachs Enzyme (HEXA)
81257
1
Alpha Thalassemia
81260
1
Familial Dysautomomia (IKBKAP)
81290
1
Mucolipidosis Type IV (MCOLN1)
81291
1
Homosystinuria due to Deficiency of MTHFR
81330
1
Niemann-Pick Disease (SMPD1)
81400
2
Spinal Muscular Atrophy
81401
2
Spinal Muscular Atrophy
81404
5
Usher Syndrome, Type 3
81405
2
X linked Severe Combined Immunodeficiency
81406
2
Maple Syrup Urine Disease, Type 1B - Full Gene Sequence
81407
1
Glycogen Storage Disease, Type III
81408
2
DMD - Muscular Dystrophy
Billable SIM Number(s)
Natera bills the patient.
3008124301 (CPT 81243)
3108140301 (CPT 81403)
Overview
Ordering Recommendations
Horizon is a carrier screen that evaluates a patient's carrier status for up to 274 autosomal-recessive and X-linked genetic conditions. There are five (5) different panels that check between 4 and 274 genetic conditions.
This test requires prior authorization (PA) and should be placed as a future order in the outpatient setting. If unable to obtain PA, please have patient sign a financial waiver.
Synonyms
Natera
Horizon
LAB123143
Specimen
Collect
This is a kit collection. Follow kit instructions for sample collection. (Two 6 mL K2 EDTA - Lavender BCT blood tubes needed).
If collecting samples for both Panorama and Horizon, draw two 10 mL Tiger Top tubes (Streck tubes) and one 6 mL K2 EDTA tube (Combo kit available from ARL).
Storage/Transport Temperature
CRITICAL ROOM TEMPERATURE
Unacceptable Conditions
Refrigerated and frozen samples.
Interpretive
Reference Interval
See interpretive report.
Coding
CPT Codes
CPT Codes for reference:
CPT CODE LIST
Test description
AMA CPT Code
Qty
Description
Panorama
81420
1
Fetal chromosomal aneuploidy (eg, trisomy 21, monosomy X) genomic sequence analysis panel, circulating cell-free fetal DNA in maternal blood
Panorama (Trisomy 21, 18 & 13)
81507
1
Fetal chromosomal aneuploidy (eg, trisomy 21, monosomy X) genomic sequence analysis panel, circulating cell-free fetal DNA in maternal blood, must include analysis of chromosomes 13, 18, and 21
Pannorama Microdeletions
81422
1
Fetal chromosomal microdeletion(s) genomic sequence analysis (eg, DiGeorge syndrome, Cri-du-chat syndrome), circulating cell-free fetal DNA in maternal blood
Horizon 4
81220
1
CFTR gene analysis; common variants
81243
1
Fragile X
81329
1
Spinal Muscular Atrophy
81161
1
DMD - Muscular Dystrophy
81408
1
DMD - Muscular Dystrophy
Horizon 27
81200
1
Canavan Disease (ASPA)
81209
1
Bloom Syndrome (BLM)
81220
1
Cystic Fibrosis (CFTR)
81242
1
FANCC
81243
1
Fragile X
81250
1
G6PC
81251
1
Gaucher Disease (GBA)
81255
1
Tay-Sachs Enzyme (HEXA)
81257
1
Alpha Thalassemia
81260
1
Familial Dysautomomia (IKBKAP)
81290
1
Mucolipidosis Type IV (MCOLN1)
81329
1
Spinal Muscular Atrophy
81330
1
Niemann-Pick Disease (SMPD1)
81361
1
HBB
81400
2
Spinal Muscular Atrophy
81401
1
Spinal Muscular Atrophy
81404
1
Usher Syndrome, Type 3
81405
1
X linked Severe Combined Immunodeficiency
81161
1
DMD - Muscular Dystrophy
81406
2
Maple Syrup Urine Disease, Type 1B - Full Gene Sequence
81408
2
DMD - Muscular Dystrophy
Horizon 106
81412
1
Ashkenazi Jewish assoc dis
Horizon 274
81200
1
Canavan Disease (ASPA)
81209
1
Bloom Syndrome (BLM)
81220
1
Cystic Fibrosis (CFTR)
81251
1
Gaucher Disease (GBA)
81205
1
BCKDHB
81238
1
F9
81242
1
FANCC
81243
1
Fragile X
81250
1
G6PC
81254
1
GJB6
81329
1
Spinal Muscular Atrophy
81361
1
HBB
81402
1
MPL
81403
1
KCNJ11
81161
1
DMD - Muscular Dystrophy
81255
1
Tay-Sachs Enzyme (HEXA)
81257
1
Alpha Thalassemia
81260
1
Familial Dysautomomia (IKBKAP)
81290
1
Mucolipidosis Type IV (MCOLN1)
81291
1
Homosystinuria due to Deficiency of MTHFR
81330
1
Niemann-Pick Disease (SMPD1)
81400
2
Spinal Muscular Atrophy
81401
2
Spinal Muscular Atrophy
81404
5
Usher Syndrome, Type 3
81405
2
X linked Severe Combined Immunodeficiency
81406
2
Maple Syrup Urine Disease, Type 1B - Full Gene Sequence
81407
1
Glycogen Storage Disease, Type III
81408
2
DMD - Muscular Dystrophy
Billable SIM Number(s)
Natera bills the patient.
3008124301 (CPT 81243)
3108140301 (CPT 81403)
Reported/Turnaround Time
Reported
Expect 2 weeks for results.
Orderable SIM Number
Orderable SIM Number(s)
CARRIER SCREENING (NATERA) (LAB123143)
This test requires prior authorization (PA) and should be placed as a future order in the outpatient setting. If unable to obtain PA, please have patient sign a financial waiver.
