Ordering Recommendations

Use to rule out Cushing syndrome or screen for thymic and bronchial carcinoid tumors.

Orderable SIM Number(s)

SALIVARY CORTISOL (LAB10005)

Synonyms

  • Free Cortisol
  • Nighttime Salivary Cortisol
  • Salivary Cortisol
  • Salivary Cushings
  • Salivary Hydrocortisone
  • LAB10005

ARUP Test Code

3016866

Patient Preparation

Collect 1 mL or more of saliva (fully saturated swab).
Do not eat for 60 minutes prior to collecting specimen.
Do not consume alcohol 12 hours prior to collecting specimen.
Do not brush teeth or use toothpaste immediately before collecting specimen, as gums may bleed and contaminate specimen, causing a falsely elevated result.
Do not use mouthwash products prior to sample collection.
Avoid using lipstick, ChapStick, and other lip items prior to sample collection.
Avoid use of exogenous sources of cortisol (e.g., topical or oral hydrocortisone) or similar products during collection to reduce contamination.
Rinse mouth thoroughly with water 10 minutes before collecting specimen.
Recommended collection time is generally between 11:00 p.m. and 1 a.m. Your healthcare provider may also require different or additional collection times. Be sure to clearly label each tube collected with correct date and time.
Specimens visibly contaminated with blood, cellular debris, food particles, or mucus must be recollected.

Collect

Saliva. Swab must be completely saturated to ensure sufficient volume for testing.

Specimen Preparation

Transfer saturated swab to plain (noncitric acid) cotton Salivette collection device (ARUP Supply #52056). Record the time of collection on the test request form and on Salivette transport container.

Storage/Transport Temperature

Refrigerated or frozen

Unacceptable Conditions

Specimens not collected using the Salivette collection device. Sodium azide preservative. Specimens visibly contaminated with blood, cellular debris, food particles, or mucus.

Stability (from collection to initiation)

Ambient: 1 week
Refrigerated: 3 weeks
Frozen: 6 months

Special Handling Instructions

Minimum volume of saliva needed is 1 mL

Reference Interval

By report

Interpretive Data

Reference Intervals:

7 a.m. to 9 a.m.: 0.1-0.75 ug/dL

3 p.m. to 5 p.m.: <0.401 ug/dL

11 p.m. to midnight: <0.1 ug/dL

CPT Codes

82533

Billable SIM Number(s)

3018253302

LOINC

  • 2142-8
Overview

Ordering Recommendations

Use to rule out Cushing syndrome or screen for thymic and bronchial carcinoid tumors.

Orderable SIM Number(s)

SALIVARY CORTISOL (LAB10005)

Synonyms

  • Free Cortisol
  • Nighttime Salivary Cortisol
  • Salivary Cortisol
  • Salivary Cushings
  • Salivary Hydrocortisone
  • LAB10005

ARUP Test Code

3016866
Specimen

Patient Preparation

Collect 1 mL or more of saliva (fully saturated swab).
Do not eat for 60 minutes prior to collecting specimen.
Do not consume alcohol 12 hours prior to collecting specimen.
Do not brush teeth or use toothpaste immediately before collecting specimen, as gums may bleed and contaminate specimen, causing a falsely elevated result.
Do not use mouthwash products prior to sample collection.
Avoid using lipstick, ChapStick, and other lip items prior to sample collection.
Avoid use of exogenous sources of cortisol (e.g., topical or oral hydrocortisone) or similar products during collection to reduce contamination.
Rinse mouth thoroughly with water 10 minutes before collecting specimen.
Recommended collection time is generally between 11:00 p.m. and 1 a.m. Your healthcare provider may also require different or additional collection times. Be sure to clearly label each tube collected with correct date and time.
Specimens visibly contaminated with blood, cellular debris, food particles, or mucus must be recollected.

Collect

Saliva. Swab must be completely saturated to ensure sufficient volume for testing.

Specimen Preparation

Transfer saturated swab to plain (noncitric acid) cotton Salivette collection device (ARUP Supply #52056). Record the time of collection on the test request form and on Salivette transport container.

Storage/Transport Temperature

Refrigerated or frozen

Unacceptable Conditions

Specimens not collected using the Salivette collection device. Sodium azide preservative. Specimens visibly contaminated with blood, cellular debris, food particles, or mucus.

Stability (from collection to initiation)

Ambient: 1 week
Refrigerated: 3 weeks
Frozen: 6 months

Special Handling Instructions

Minimum volume of saliva needed is 1 mL

Interpretive

Reference Interval

By report

Interpretive Data

Reference Intervals:

7 a.m. to 9 a.m.: 0.1-0.75 ug/dL

3 p.m. to 5 p.m.: <0.401 ug/dL

11 p.m. to midnight: <0.1 ug/dL

Coding

CPT Codes

82533

Billable SIM Number(s)

3018253302

LOINC

  • 2142-8