Preferred CSF reflex panel for the workup of suspected neuroborreliosis.
Orderable SIM Number(s)
B. BURGDORFERI ANTIBODIES, CSF (LAB789)
Synonyms
Lyme Antibodies, Total (CSF)
Spinal Fluid Lyme Antibody
Borrelia Burgdorferi Ab. CSF
Lyme Disease Ab CSF, ELISA
Lyme Antibodies, Total
Lyme Disease
LAB789
Lyme Disease CSF Abs Reflex Panel
ARUP Test Code
3016760
Collect
CSF. New York State Clients: CSF and serum separator tube (SST) or plain red. Serum specimen should be drawn within 24 hours of CSF collection.
Specimen Preparation
Transfer 6 mL CSF to an ARUP standard transport tube. (Min: 2.5 mL) New York State Clients: Transfer 2 mL CSF (Min: 1 mL) to an ARUP standard transport tube AND transfer 2 mL serum to an ARUP standard transport tube.
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Bacterially contaminated, heat-inactivated, hemolyzed, or xanthochromic specimens.
The detection of antibodies to Borrelia burgdorferi in cerebrospinal fluid may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier. Lyme disease diagnosis in serum is recommended prior to any CSF studies.
Component
Interpretation
B. burgdorferi VlsE1/pepC10 Abs, ELISA
0.90 IV or less: Negative; VlsE1 and pepC10 antibodies to B. burgdorferi not detected. 0.91-1.09 IV: Equivocal; repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive; VlsE1 and pepC10 antibodies to B. burgdorferi detected.
Notes
If VlsE1/pepC10 antibodies by ELISA is 0.91 IV or greater, then B. burgdorferi IgG antibody by immunoblot and IgM antibody by immunoblot will be added. Additional charges apply.
CPT Codes
86618; if reflexed, add 86617 x2
Billable SIM Number(s)
3028661802 (CPT 86618)
3028661701 (CPT 86617)
LOINC
103961-9
Overview
Ordering Recommendations
Preferred CSF reflex panel for the workup of suspected neuroborreliosis.
Orderable SIM Number(s)
B. BURGDORFERI ANTIBODIES, CSF (LAB789)
Synonyms
Lyme Antibodies, Total (CSF)
Spinal Fluid Lyme Antibody
Borrelia Burgdorferi Ab. CSF
Lyme Disease Ab CSF, ELISA
Lyme Antibodies, Total
Lyme Disease
LAB789
Lyme Disease CSF Abs Reflex Panel
ARUP Test Code
3016760
Specimen
Collect
CSF. New York State Clients: CSF and serum separator tube (SST) or plain red. Serum specimen should be drawn within 24 hours of CSF collection.
Specimen Preparation
Transfer 6 mL CSF to an ARUP standard transport tube. (Min: 2.5 mL) New York State Clients: Transfer 2 mL CSF (Min: 1 mL) to an ARUP standard transport tube AND transfer 2 mL serum to an ARUP standard transport tube.
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Bacterially contaminated, heat-inactivated, hemolyzed, or xanthochromic specimens.
The detection of antibodies to Borrelia burgdorferi in cerebrospinal fluid may indicate central nervous system infection. However, consideration must be given to possible contamination by blood or transfer of serum antibodies across the blood-brain barrier. Lyme disease diagnosis in serum is recommended prior to any CSF studies.
Component
Interpretation
B. burgdorferi VlsE1/pepC10 Abs, ELISA
0.90 IV or less: Negative; VlsE1 and pepC10 antibodies to B. burgdorferi not detected. 0.91-1.09 IV: Equivocal; repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive; VlsE1 and pepC10 antibodies to B. burgdorferi detected.
Notes
If VlsE1/pepC10 antibodies by ELISA is 0.91 IV or greater, then B. burgdorferi IgG antibody by immunoblot and IgM antibody by immunoblot will be added. Additional charges apply.
