Use to diagnose and monitor carcinoid tumors. Preferred serotonin test since most of the blood serotonin resides in the platelets.
Orderable SIM Number(s)
SEROTONIN SERUM (LAB121)
Synonyms
5-HT, Blood
5-Hydroxytryptamine, Blood
5-HT
5-Hydroxy Tryptamine
5-Hydroxytryptamine
LAB121
ARUP Test Code
0080395
Patient Preparation
Abstain from medications for 72 hours prior to collection.
Collect
Lavender (EDTA) or pink (K2EDTA).
Specimen Preparation
Place on ice. Transfer 3 mL whole blood to an ARUP Serotonin Transport Tube containing ascorbic acid (ARUP supply #16568). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) Mix well. Specimen must be preserved and frozen within 2 hours of collection.
Storage/Transport Temperature
Once sample is transferred to the ARUP Serotonin Transport Tube, FREEZEIMMEDIATELY
Unacceptable Conditions
Non-frozen specimens. Specimens other than whole blood.
Stability (from collection to initiation)
After transfer to Serotonin Transport Tube: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Special Handling Instructions
Remarks
Serotonin, Serum (ARUP test code 0080397) is recommended for patients that are difficult to draw.
Reference Interval
50-200 ng/mL
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Notes
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.
CPT Codes
84260
Billable SIM Number(s)
3018426001
LOINC
2939-7
Overview
Ordering Recommendations
Use to diagnose and monitor carcinoid tumors. Preferred serotonin test since most of the blood serotonin resides in the platelets.
Orderable SIM Number(s)
SEROTONIN SERUM (LAB121)
Synonyms
5-HT, Blood
5-Hydroxytryptamine, Blood
5-HT
5-Hydroxy Tryptamine
5-Hydroxytryptamine
LAB121
ARUP Test Code
0080395
Specimen
Patient Preparation
Abstain from medications for 72 hours prior to collection.
Collect
Lavender (EDTA) or pink (K2EDTA).
Specimen Preparation
Place on ice. Transfer 3 mL whole blood to an ARUP Serotonin Transport Tube containing ascorbic acid (ARUP supply #16568). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) Mix well. Specimen must be preserved and frozen within 2 hours of collection.
Storage/Transport Temperature
Once sample is transferred to the ARUP Serotonin Transport Tube, FREEZEIMMEDIATELY
Unacceptable Conditions
Non-frozen specimens. Specimens other than whole blood.
Stability (from collection to initiation)
After transfer to Serotonin Transport Tube: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month
Special Handling Instructions
Remarks
Serotonin, Serum (ARUP test code 0080397) is recommended for patients that are difficult to draw.
Interpretive
Reference Interval
50-200 ng/mL
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Notes
Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.
Coding
CPT Codes
84260
Billable SIM Number(s)
3018426001
LOINC
2939-7
Performed
Performed
Mon, Wed, Thu, Fri, Sat
Reported/Turnaround Time
Reported
2-6 days
Methodology
Methodology
Quantitative High Performance Liquid Chromatography (HPLC)
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