LAB7598 Effective 6/1/20: New collection container for testing to be done at Mayo Clinical Labs.
Contact UH Clinical Lab to obtain collection containers.
Performing Lab
Mayo Clinical Labs (test code: ADEVL)
Collect
Collect 2 mL of spinal fluid (CSF). Send 2 mL CSF in CSF AD Biomarker Tube (Sarstedt w/blue lid)
Note: CSF sample MUST be collected in the CSF AD Biomarker tube. Do not aliquot. Testing is performed directly from collection container.
Patient Preparation
For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
Specimen Preparation
Collect CSF directly in CSF AD Biomarker tube.
Pediatric Collection
1.5 to 2.5 mL CSF
Unacceptable Conditions
Polystyrene collection tubes are not acceptable. Exposure of CSF to polystyrene tubes may result in falsely low Abeta42 concentrations. For more information see Cautions.
*The Alzheimer's Association consensus protocol for handling of CSF for clinical measurements of Abeta42 and tau recommends using the drip method for CSF collection and directly collecting into a low bind polypropylene tube. Although some clinicians prefer the syringe pull method due to speed of collection, the drip method reduces the risk of Abeta42 binding to the plastic of any syringe used.
Storage/Transport Temperature
Deliver to the lab ASAP or deliver refrigerated
Ambient: 12 hours
Refrigerated: 14 days
Frozen: 30 days
Performed
Mayo Clinical Labs
Stability (from collection to initiation)
Ambient: 12 hours
Refrigerated: 14 days
Frozen: 30 days (preferred)
Performed
Mayo Clinical Labs
Methodology
Electrochemiluminescent Immunoassay (ECLIA)
Reported
DAY(S) PERFORMED: Tuesday, Friday
REPORT AVAILABLE: 1 to 4 days
Synonyms
ADEVL
AD Evaluation
Amyloid-Beta 42 Protein
ADMARK Proteins
EPIC Code
LAB7598 Effective 6/1/20: New collection container for testing to be done at Mayo Clinical Labs.
Contact UH Clinical Lab to obtain collection containers.
Reference Interval
Beta-amyloid (1-42) (Abeta42): >834 pg/mL
Total-Tau: < or =238 pg/mL
Phosphorylated-Tau 181: < or =21.6 pg/mL
p-Tau/Abeta42: < or =0.028
Interpretive Data
CPT Codes
83520 x 3
Collection
EPIC Code
LAB7598 Effective 6/1/20: New collection container for testing to be done at Mayo Clinical Labs.
Contact UH Clinical Lab to obtain collection containers.
Performing Lab
Mayo Clinical Labs (test code: ADEVL)
Collect
Collect 2 mL of spinal fluid (CSF). Send 2 mL CSF in CSF AD Biomarker Tube (Sarstedt w/blue lid)
Note: CSF sample MUST be collected in the CSF AD Biomarker tube. Do not aliquot. Testing is performed directly from collection container.
Patient Preparation
For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
Specimen Preparation
Collect CSF directly in CSF AD Biomarker tube.
Pediatric Collection
1.5 to 2.5 mL CSF
Unacceptable Conditions
Polystyrene collection tubes are not acceptable. Exposure of CSF to polystyrene tubes may result in falsely low Abeta42 concentrations. For more information see Cautions.
*The Alzheimer's Association consensus protocol for handling of CSF for clinical measurements of Abeta42 and tau recommends using the drip method for CSF collection and directly collecting into a low bind polypropylene tube. Although some clinicians prefer the syringe pull method due to speed of collection, the drip method reduces the risk of Abeta42 binding to the plastic of any syringe used.
Storage/Transport Temperature
Deliver to the lab ASAP or deliver refrigerated
Ambient: 12 hours
Refrigerated: 14 days
Frozen: 30 days
Performed
Mayo Clinical Labs
Stability (from collection to initiation)
Ambient: 12 hours
Refrigerated: 14 days
Frozen: 30 days (preferred)
Ordering
Performed
Mayo Clinical Labs
Methodology
Electrochemiluminescent Immunoassay (ECLIA)
Reported
DAY(S) PERFORMED: Tuesday, Friday
REPORT AVAILABLE: 1 to 4 days
Synonyms
ADEVL
AD Evaluation
Amyloid-Beta 42 Protein
ADMARK Proteins
EPIC Code
LAB7598 Effective 6/1/20: New collection container for testing to be done at Mayo Clinical Labs.
Contact UH Clinical Lab to obtain collection containers.
Result Interpretation
Reference Interval
Beta-amyloid (1-42) (Abeta42): >834 pg/mL
Total-Tau: < or =238 pg/mL
Phosphorylated-Tau 181: < or =21.6 pg/mL
p-Tau/Abeta42: < or =0.028
