Refer to Specimen stability criteria as shown below
Ambient
72 hours
Refrigerated
7 days
Frozen
14 days
Unacceptable Conditions
Specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens, specimens submitted in leaking containers
Special Instructions
This test requires its own lavender top. Collecting sample just before the next dose will be adequate for monitoring purposes. Optimal response to Cyclosporine is usually associated with the trough blood concentration (i.e., the minimum concentration experienced just before the next dose).
CPT Codes
80158
Synonyms
Neoral
Sandimmune
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS)
Performing Location
Chemistry (Toxicology)
Reported STAT
2 hours
Reported Routine
6 hours
Additional Information
This test was performed using liquid chromatography tandem mass spectrometry. This test was developed and its performance characteristics were determined by the University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been approved by the FDA, however, approval is not required for clinical use.
Test set up frequency
Daily (Cut-off time 12:00 Noon)
Reference Interval
Liver Transplants, suggested therapeutic ranges:
<6 Months post tranplant: 300-400 ng/mL
>6 Months post transplant: 150-250 ng/mL
>1 Year post transplant: 100-200 ng/mL
Rental Transplant: 100-400 ng/mL
Cardiac Tranplant: 100-400 ng/mL
Bone Marrow Transplant: 200-300 ng/mL
Critical Value (automatic call-back): > 450 ng/mL
Additional Information
This test was performed using liquid chromatography tandem mass spectrometry. This test was developed and its performance characteristics were determined by the University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been approved by the FDA, however, approval is not required for clinical use.
Collection
Collect
3.0 mL whole blood in lavender-top (EDTA) tube(s)
Specimen Required
1.0 mL whole blood
Specimen Min Vol
0.5 mL whole blood
Specimen Preparation
None
Storage/Transport Temperature
Refer to Specimen stability criteria as shown below
Ambient
72 hours
Refrigerated
7 days
Frozen
14 days
Unacceptable Conditions
Specimens that exceed stated stability, unlabeled/mislabeled/mismatched specimens, specimens submitted in leaking containers
Special Instructions
This test requires its own lavender top. Collecting sample just before the next dose will be adequate for monitoring purposes. Optimal response to Cyclosporine is usually associated with the trough blood concentration (i.e., the minimum concentration experienced just before the next dose).
Test Info
CPT Codes
80158
Synonyms
Neoral
Sandimmune
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS)
Performing Location
Chemistry (Toxicology)
Reported STAT
2 hours
Reported Routine
6 hours
Additional Information
This test was performed using liquid chromatography tandem mass spectrometry. This test was developed and its performance characteristics were determined by the University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been approved by the FDA, however, approval is not required for clinical use.
Test set up frequency
Daily (Cut-off time 12:00 Noon)
Result Interpretation
Reference Interval
Liver Transplants, suggested therapeutic ranges:
<6 Months post tranplant: 300-400 ng/mL
>6 Months post transplant: 150-250 ng/mL
>1 Year post transplant: 100-200 ng/mL
Rental Transplant: 100-400 ng/mL
Cardiac Tranplant: 100-400 ng/mL
Bone Marrow Transplant: 200-300 ng/mL
Critical Value (automatic call-back): > 450 ng/mL
Additional Information
This test was performed using liquid chromatography tandem mass spectrometry. This test was developed and its performance characteristics were determined by the University of California Irvine Medical Center, Department of Pathology and Laboratory Medicine. It has not been approved by the FDA, however, approval is not required for clinical use.
