Specimens less than 0.25 mg (dry weight). Specimens stored or shipped in saline.
Specimen Preparation
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens should be stored and transported in a metal-free container such as a royal blue (no additive).
Ordering Recommendations
Useful in confirming hepatic iron overload, particularly in individuals with hemochromatosis and no common HFE mutations. Initial approach to diagnosis for hemochromatosis should include Iron and Iron Binding Capacity (0020420) (NOTE: test includes serum transferrin saturation) and Ferritin (0070065).
A Hepatic Iron Index (HII) is not calculated for patients less than 14 years. An HII less than 1.0 is consistent with normal iron accumulation. An HII 1.0 through 1.9 is consistent with mild iron accumulation such as in heterozygous hemochromatosis or alcoholic liver disease. An HII greater than 1.9 is consistent with iron overload such as in homozygous hemochromatosis, porphyria cutanea tarda, and cirrhotic liver disease. The HII will decrease with chelation, chronic blood loss, or phlebotomy.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
ARUP Test Code
0028250
LOINC
29638-4
15357-7
49061-5
11526-1
CPT Codes
83540
Test Information
EPIC Lab Number
LAB4572
Collect
Liver tissue obtained with an 18 gauge needle.
Additional Requirements
Collect: Paraffin Block
Auto Lab Accepts:
Unacceptable Conditions
Specimens less than 0.25 mg (dry weight). Specimens stored or shipped in saline.
Specimen Preparation
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens should be stored and transported in a metal-free container such as a royal blue (no additive).
Ordering Recommendations
Useful in confirming hepatic iron overload, particularly in individuals with hemochromatosis and no common HFE mutations. Initial approach to diagnosis for hemochromatosis should include Iron and Iron Binding Capacity (0020420) (NOTE: test includes serum transferrin saturation) and Ferritin (0070065).
A Hepatic Iron Index (HII) is not calculated for patients less than 14 years. An HII less than 1.0 is consistent with normal iron accumulation. An HII 1.0 through 1.9 is consistent with mild iron accumulation such as in heterozygous hemochromatosis or alcoholic liver disease. An HII greater than 1.9 is consistent with iron overload such as in homozygous hemochromatosis, porphyria cutanea tarda, and cirrhotic liver disease. The HII will decrease with chelation, chronic blood loss, or phlebotomy.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
