Submission of a completed Prenatal Genetic Test Requisition Form is required. To access the form, please click on Lab Form link at the bottom of this page.

Please collect minimum of 15 mL amniotic fluid in a non-toxic, sterile container. Transport the sample at room temperature and send to the laboratory within 24 hours from collection time. DO NOT freeze the sample.

• If Aneuploidy FISH Screen for common aneuploidies (chromosomes 13, 18, 21, X and Y; see test code: GEN3) is also ordered, submit additional 5-10 mL amniotic fluid.
• If amniotic fluid AFP with reflex to AChE and fetal hemoglobin, infectious disease qualitative PCR, and/or 7-dehydrocholesterol biochemical study (Smith-Lemli-Opitz syndrome testing) is also ordered, submit 2-3 mL additional amniotic fluid. Although direct (unspun) fluid is always preferred, supernatant fluid can also be used as alternate sample for these tests.
• If Prenatal Microarray Analysis is also desired, please submit maternal sample (4 mL blood in EDTA tube) for maternal cell contamination study.
• If additional testing on cultured amniocytes is also ordered (e.g., send out cultured cells to another laboratory), submit additional 5-10 mL amniotic fluid and call Cytogenetics Lab to speak with a laboratory genetic counselor to coordinate. For molecular genetic testing to be performed on cultured amniocytes, submission of maternal sample (4 mL blood in EDTA tube) is also recommended to perform maternal cell contamination study.
• For sending out cultured amniocytes to another reference laboratory or to perform DNA isolation on cultured amniocytes, additional culture charge will be billed (under additional CPT code 88235).
• If cryopreservation of cultured cells is requested, a portion of cultured cells will be frozen and stored for possible future testing. Cryopreservation charge will apply (CPT code 88240).

This test is used to evaluate fetal chromosomes for numerical and gross structural abnormalities (e.g. translocations, inversions). Common indications for study include advanced maternal age, abnormal prenatal screening test such as maternal serum quad screen or noninvasive prenatal testing/screening (NIPT/NIPS), abnormal fetal ultrasound exam, and family history of chromosome abnormality.

For this test, fetal cells contained in amniotic fluid will be cultured, then cultured metaphase cells will be used to perform chromosome analysis. Cells from 15 colonies will be evaluated for this test, unless poor cell growth prohibits. Turnaround time for results varies depending on the rate of cell growth in culture, but results are typically available in 8-10 days. To evaluate for the presence of low-level mosaicism for chromosomal abnormalities, mosaicism study can be ordered along with chromosome analysis (which will be performed with extra charges, CPT code 88263), and chromosomes in additional colonies will be evaluated. To request for mosaicism study, please indicate this request on the test requisition form.

If additional FISH or mosaicism studies are recommended to assist in the result interpretation by the director, the clinician will be notified.

Submission of a completed Prenatal Genetic Test Requisition Form is required. To access the form, please click on Lab Form link at the bottom of this page.

Please collect minimum of 15 mL amniotic fluid in a non-toxic, sterile container. Transport the sample at room temperature and send to the laboratory within 24 hours from collection time. DO NOT freeze the sample.

• If Aneuploidy FISH Screen for common aneuploidies (chromosomes 13, 18, 21, X and Y; see test code: GEN3) is also ordered, submit additional 5-10 mL amniotic fluid.
• If amniotic fluid AFP with reflex to AChE and fetal hemoglobin, infectious disease qualitative PCR, and/or 7-dehydrocholesterol biochemical study (Smith-Lemli-Opitz syndrome testing) is also ordered, submit 2-3 mL additional amniotic fluid. Although direct (unspun) fluid is always preferred, supernatant fluid can also be used as alternate sample for these tests.
• If Prenatal Microarray Analysis is also desired, please submit maternal sample (4 mL blood in EDTA tube) for maternal cell contamination study.
• If additional testing on cultured amniocytes is also ordered (e.g., send out cultured cells to another laboratory), submit additional 5-10 mL amniotic fluid and call Cytogenetics Lab to speak with a laboratory genetic counselor to coordinate. For molecular genetic testing to be performed on cultured amniocytes, submission of maternal sample (4 mL blood in EDTA tube) is also recommended to perform maternal cell contamination study.
• For sending out cultured amniocytes to another reference laboratory or to perform DNA isolation on cultured amniocytes, additional culture charge will be billed (under additional CPT code 88235).
• If cryopreservation of cultured cells is requested, a portion of cultured cells will be frozen and stored for possible future testing. Cryopreservation charge will apply (CPT code 88240).

This test is used to evaluate fetal chromosomes for numerical and gross structural abnormalities (e.g. translocations, inversions). Common indications for study include advanced maternal age, abnormal prenatal screening test such as maternal serum quad screen or noninvasive prenatal testing/screening (NIPT/NIPS), abnormal fetal ultrasound exam, and family history of chromosome abnormality.

For this test, fetal cells contained in amniotic fluid will be cultured, then cultured metaphase cells will be used to perform chromosome analysis. Cells from 15 colonies will be evaluated for this test, unless poor cell growth prohibits. Turnaround time for results varies depending on the rate of cell growth in culture, but results are typically available in 8-10 days. To evaluate for the presence of low-level mosaicism for chromosomal abnormalities, mosaicism study can be ordered along with chromosome analysis (which will be performed with extra charges, CPT code 88263), and chromosomes in additional colonies will be evaluated. To request for mosaicism study, please indicate this request on the test requisition form.

If additional FISH or mosaicism studies are recommended to assist in the result interpretation by the director, the clinician will be notified.

This test is used to evaluate fetal chromosomes for numerical and gross structural abnormalities (e.g. translocations, inversions). Common indications for study include advanced maternal age, abnormal prenatal screening test such as maternal serum quad screen or noninvasive prenatal testing/screening (NIPT/NIPS), abnormal fetal ultrasound exam, and family history of chromosome abnormality.

For this test, fetal cells contained in amniotic fluid will be cultured, then cultured metaphase cells will be used to perform chromosome analysis. Cells from 15 colonies will be evaluated for this test, unless poor cell growth prohibits. Turnaround time for results varies depending on the rate of cell growth in culture, but results are typically available in 8-10 days. To evaluate for the presence of low-level mosaicism for chromosomal abnormalities, mosaicism study can be ordered along with chromosome analysis (which will be performed with extra charges, CPT code 88263), and chromosomes in additional colonies will be evaluated. To request for mosaicism study, please indicate this request on the test requisition form.

If additional FISH or mosaicism studies are recommended to assist in the result interpretation by the director, the clinician will be notified.

Submission of a completed Prenatal Genetic Test Requisition Form is required. To access the form, please click on Lab Form link at the bottom of this page.

Please collect minimum of 15 mL amniotic fluid in a non-toxic, sterile container. Transport the sample at room temperature and send to the laboratory within 24 hours from collection time. DO NOT freeze the sample.

• If Aneuploidy FISH Screen for common aneuploidies (chromosomes 13, 18, 21, X and Y; see test code: GEN3) is also ordered, submit additional 5-10 mL amniotic fluid.
• If amniotic fluid AFP with reflex to AChE and fetal hemoglobin, infectious disease qualitative PCR, and/or 7-dehydrocholesterol biochemical study (Smith-Lemli-Opitz syndrome testing) is also ordered, submit 2-3 mL additional amniotic fluid. Although direct (unspun) fluid is always preferred, supernatant fluid can also be used as alternate sample for these tests.
• If Prenatal Microarray Analysis is also desired, please submit maternal sample (4 mL blood in EDTA tube) for maternal cell contamination study.
• If additional testing on cultured amniocytes is also ordered (e.g., send out cultured cells to another laboratory), submit additional 5-10 mL amniotic fluid and call Cytogenetics Lab to speak with a laboratory genetic counselor to coordinate. For molecular genetic testing to be performed on cultured amniocytes, submission of maternal sample (4 mL blood in EDTA tube) is also recommended to perform maternal cell contamination study.
• For sending out cultured amniocytes to another reference laboratory or to perform DNA isolation on cultured amniocytes, additional culture charge will be billed (under additional CPT code 88235).
• If cryopreservation of cultured cells is requested, a portion of cultured cells will be frozen and stored for possible future testing. Cryopreservation charge will apply (CPT code 88240).

This test is used to evaluate fetal chromosomes for numerical and gross structural abnormalities (e.g. translocations, inversions). Common indications for study include advanced maternal age, abnormal prenatal screening test such as maternal serum quad screen or noninvasive prenatal testing/screening (NIPT/NIPS), abnormal fetal ultrasound exam, and family history of chromosome abnormality.

For this test, fetal cells contained in amniotic fluid will be cultured, then cultured metaphase cells will be used to perform chromosome analysis. Cells from 15 colonies will be evaluated for this test, unless poor cell growth prohibits. Turnaround time for results varies depending on the rate of cell growth in culture, but results are typically available in 8-10 days. To evaluate for the presence of low-level mosaicism for chromosomal abnormalities, mosaicism study can be ordered along with chromosome analysis (which will be performed with extra charges, CPT code 88263), and chromosomes in additional colonies will be evaluated. To request for mosaicism study, please indicate this request on the test requisition form.

If additional FISH or mosaicism studies are recommended to assist in the result interpretation by the director, the clinician will be notified.