Ordering Recommendations

In the absence of active lesions, this is the preferred serology test for diagnosing herpes simplex viral infection.

Collection Container

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimen. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Unacceptable Conditions

Plasma or urine. Contaminated, heat-inactivated, hemolyzed or lipemic specimens.

Notes

For CSF, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050379) and Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050359).

Referral Lab

Laboratories.

Reference Interval

Components
Reference Interval
HSV 1 Glycoprotein G Ab, IgG0.89 IV or less
HSV 2 Glycoprotein G Antibody, IgG0.89 IV or less

Interpretive Data

Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a non-type specific screening test.

False positive results are possible. Consider additional testing for HSV-2, particularly if the result for HSV-2 is </= 3.0 IV.

Component Interpretation
Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.
Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibody to HSV type 2 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

CPT Codes

86695; 86696

LOINC

  • 42337-6
  • 42338-4

ARUP Test Code

0051152
Collection & Processing

Ordering Recommendations

In the absence of active lesions, this is the preferred serology test for diagnosing herpes simplex viral infection.

Collection Container

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimen. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Stability (from collection to initiation)

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Unacceptable Conditions

Plasma or urine. Contaminated, heat-inactivated, hemolyzed or lipemic specimens.

Notes

For CSF, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050379) and Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050359).

Referral Lab

Laboratories.
CR&P Information
Result Interpretation

Reference Interval

Components
Reference Interval
HSV 1 Glycoprotein G Ab, IgG0.89 IV or less
HSV 2 Glycoprotein G Antibody, IgG0.89 IV or less

Interpretive Data

Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a non-type specific screening test.

False positive results are possible. Consider additional testing for HSV-2, particularly if the result for HSV-2 is </= 3.0 IV.

Component Interpretation
Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.
Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA0.89 IV or less: Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.09 IV: Equivocal - Questionable presence of IgG antibody to HSV type 2 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

Testing Updates
Billing Codes

CPT Codes

86695; 86696

LOINC

  • 42337-6
  • 42338-4

ARUP Test Code

0051152

Ordering Information

Cerner Orderable
HSV 1,2 Glyco G-Specific, IgG by CIA; HSV12GY
Penn Chart Orderable
HSV 1,2 Glyco G-Specific, IgG; HSV12GY
Performing Lab
ARUP
Performed
Sun-Sat
Reported
1-2 days
Methodology
Semi-Quantitative Chemiluminescent Immunoassay
Synonyms
  • Herpes Simplex Antibodies, IgG
  • Herpes Simplex Serology, Serum HSV 1,2
  • HSV 1 and 2
  • HSV 1, 2 IgG
  • HSV 1,2
  • HSV
  • HSV glycoprotein G type 1 and 2
  • HSV typing 1 and 2

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