Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
Synonyms
ENA
anti-SM
anti-RNP
anti-ENA
anti-smith
RNP antibody
Sm antibody
Smith antibody
Sm/RNP
Sample Type
Serum
Collect
Gold top
Amount to Collect
2 mL blood
Preferred Volume
1 mL serum
Minimum Volume
0.5 mL serum
Remarks
Avoid hemolysis
Unacceptable Conditions
Grossly hemolyzed, lipemic or icteric samples.
Test Code
AENA
Performing Lab
Immunology
Specimen Preparation
Freeze serum at -20C
Preferred Volume
1 mL serum
Minimum Volume
0.5 mL serum
Unacceptable Conditions
Grossly hemolyzed, lipemic or icteric samples.
Units
Chemiluminescent Units (CU)
Reference Interval
For both anti-SM and anti-RNP:
Negative: < 20 CU
Positive: >= 20 CU
Additional Information
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
CPT Codes
86235 x 2
LOINC Codes
43182-5
Available Stat
No
Test Code
AENA
Performing Lab
Immunology
Performed
Friday (day shift)
Methodology
Chemiluminescent
Remarks
Avoid hemolysis
Collect
Gold top
Amount to Collect
2 mL blood
Sample Type
Serum
Preferred Volume
1 mL serum
Minimum Volume
0.5 mL serum
Unacceptable Conditions
Grossly hemolyzed, lipemic or icteric samples.
Specimen Preparation
Freeze serum at -20C
Units
Chemiluminescent Units (CU)
Reference Interval
For both anti-SM and anti-RNP:
Negative: < 20 CU
Positive: >= 20 CU
Synonyms
ENA
anti-SM
anti-RNP
anti-ENA
anti-smith
RNP antibody
Sm antibody
Smith antibody
Sm/RNP
Reported
2-8 days
Additional Information
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
CPT Codes
86235 x 2
LOINC Codes
43182-5
Ordering
Available Stat
No
Performing Lab
Immunology
Performed
Friday (day shift)
Methodology
Chemiluminescent
Reported
2-8 days
Additional Information
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
Synonyms
ENA
anti-SM
anti-RNP
anti-ENA
anti-smith
RNP antibody
Sm antibody
Smith antibody
Sm/RNP
Collection
Sample Type
Serum
Collect
Gold top
Amount to Collect
2 mL blood
Preferred Volume
1 mL serum
Minimum Volume
0.5 mL serum
Remarks
Avoid hemolysis
Unacceptable Conditions
Grossly hemolyzed, lipemic or icteric samples.
Processing
Test Code
AENA
Performing Lab
Immunology
Specimen Preparation
Freeze serum at -20C
Preferred Volume
1 mL serum
Minimum Volume
0.5 mL serum
Unacceptable Conditions
Grossly hemolyzed, lipemic or icteric samples.
Result Interpretation
Units
Chemiluminescent Units (CU)
Reference Interval
For both anti-SM and anti-RNP:
Negative: < 20 CU
Positive: >= 20 CU
Additional Information
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
Administrative
CPT Codes
86235 x 2
LOINC Codes
43182-5
Complete View
Available Stat
No
Test Code
AENA
Performing Lab
Immunology
Performed
Friday (day shift)
Methodology
Chemiluminescent
Remarks
Avoid hemolysis
Collect
Gold top
Amount to Collect
2 mL blood
Sample Type
Serum
Preferred Volume
1 mL serum
Minimum Volume
0.5 mL serum
Unacceptable Conditions
Grossly hemolyzed, lipemic or icteric samples.
Specimen Preparation
Freeze serum at -20C
Units
Chemiluminescent Units (CU)
Reference Interval
For both anti-SM and anti-RNP:
Negative: < 20 CU
Positive: >= 20 CU
Synonyms
ENA
anti-SM
anti-RNP
anti-ENA
anti-smith
RNP antibody
Sm antibody
Smith antibody
Sm/RNP
Reported
2-8 days
Additional Information
Systemic lupus erythematosus (SLE) is characterized by the presence of autoantibodies. One class of autoantibodies is directed against extractable nuclear antigens, often producing a speckled pattern on ANA screening.
Antibodies to Sm are present in approximately 40% of patients with SLE and are considered to be highly specific markers for this disease.
The RNP antigen is closely associated with the Sm antigen and is designated the Sm/RNP complex. Anti-RNP antibodies are found in a variety of rheumatic diseases including scleroderma, rheumatoid arthritis, discoid lupus, polymyositis, and Sjogren's syndrome.
