After specimen receipt in the Clinical Genomics Lab, results are generally available within 16 days.
Add-on Eligibility
Yes, within 7 days of collection *If DNA has been extracted previously for other Clinical Genomics tests, this is stored for 6 weeks and may qualify for add-on
Specimen Type
Blood
Specimen Volume
Adult: 5 mL (Minimum: 1 mL) Pediatric: 1 mL (Minimum: 1 mL)
Collection Container
EDTA Whole Blood Tube (Lavender Top Vacutainer)
Pediatric Collection
3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)
Unacceptable Conditions
Severely clotted or grossly hemolyzed specimens
Specimens that have been improperly collected, stored, or transported
Specimens collected in preservatives other than EDTA
ACD tubes are accepted, but EDTA is preferred
Serum or plasma
Specimens that have been frozen
Commingled specimens
Specimens in tubes that have been damaged or broken during transport
Specimens with insufficient volume for testing
Unlabeled or mislabeled specimens
Storage/Transport Temperature
Transport Instructions
Collection Location
Transport Temperature
Processing Required
Timeframe
ED/Inpatient
Room Temperature
None
Specimen must be received by the lab within 3 days of collection
Laboratory/Outpatient/Off-Site
Room Temperature
None
Specimen must be received by the lab within 3 days of collection
Storage: Refrigerated
Stability (from collection to initiation)
Stability:
Prior to Extraction:
Room Temperature: 3 days
Refrigerated: 7 days
Frozen: Unacceptable
Extracted DNA:
Room Temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: Indefinitely
Laboratory Storage:
Original Specimen: Refrigerated
Extracted DNA: Frozen
Laboratory Retention:
Original Specimen: 1 month
Extracted DNA: 6 weeks
Collection Instructions
Labeling Instructions:
When labeling blood tubes, leave a small window visible for the lab to assess the fill volume and sample integrity
Ensure that the barcode is in the correct orientation.
Collection Instructions:
Follow the correct order of draw when collecting with additional orders and tube types:
Reference Interval
By Report
Interpretive Data
Refer to report for result specific interpretation details
The NGS Hematologic Malignancy Mutation Panel targets a total of 123 clinically relevant genes. Specifically the panel interrogates all exons of 95 genes and key exons in an additional 28 genes for the presence of sequence variants known to be frequently mutated in hematological malignancies. These genes were chosen because they impact diagnosis, prognosis, or therapy efficacy for both myeloid malignancies (myeloproliferative neoplasms, myelodysplastic syndrome, acute myeloid leukemia) and lymphoid malignancies (acute lymphocytic leukemia, chronic lymphocytic leukemia, non-Hodgkin’s lymphoma, and multiple myeloma).
Ordering
Performed
Weekly
Methodology
Next Generation Sequencing (NGS)
Reported
Routine: 16 days from receipt of specimen
Synonyms
Clinical Genomics
Lymphoid Malignancies
Myeloid Malignancies
Malignant Hematological Disorders
Hematologic Malignancies
Hematological Malignancy Panel
Hematological Malignancies
Performing Lab
Clinical Genomics
CPT Codes
81455
Turnaround Time
After specimen receipt in the Clinical Genomics Lab, results are generally available within 16 days.
Add-on Eligibility
Yes, within 7 days of collection *If DNA has been extracted previously for other Clinical Genomics tests, this is stored for 6 weeks and may qualify for add-on
Collection
Specimen Type
Blood
Specimen Volume
Adult: 5 mL (Minimum: 1 mL) Pediatric: 1 mL (Minimum: 1 mL)
Collection Container
EDTA Whole Blood Tube (Lavender Top Vacutainer)
Pediatric Collection
3.0 mL EDTA Whole Blood Tube (Lavender Top Vacutainer)
Unacceptable Conditions
Severely clotted or grossly hemolyzed specimens
Specimens that have been improperly collected, stored, or transported
Specimens collected in preservatives other than EDTA
ACD tubes are accepted, but EDTA is preferred
Serum or plasma
Specimens that have been frozen
Commingled specimens
Specimens in tubes that have been damaged or broken during transport
Specimens with insufficient volume for testing
Unlabeled or mislabeled specimens
Storage/Transport Temperature
Transport Instructions
Collection Location
Transport Temperature
Processing Required
Timeframe
ED/Inpatient
Room Temperature
None
Specimen must be received by the lab within 3 days of collection
Laboratory/Outpatient/Off-Site
Room Temperature
None
Specimen must be received by the lab within 3 days of collection
Storage: Refrigerated
Stability (from collection to initiation)
Stability:
Prior to Extraction:
Room Temperature: 3 days
Refrigerated: 7 days
Frozen: Unacceptable
Extracted DNA:
Room Temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: Indefinitely
Laboratory Storage:
Original Specimen: Refrigerated
Extracted DNA: Frozen
Laboratory Retention:
Original Specimen: 1 month
Extracted DNA: 6 weeks
Collection Instructions
Labeling Instructions:
When labeling blood tubes, leave a small window visible for the lab to assess the fill volume and sample integrity
Ensure that the barcode is in the correct orientation.
Collection Instructions:
Follow the correct order of draw when collecting with additional orders and tube types:
Result Interpretation
Reference Interval
By Report
Interpretive Data
Refer to report for result specific interpretation details
The NGS Hematologic Malignancy Mutation Panel targets a total of 123 clinically relevant genes. Specifically the panel interrogates all exons of 95 genes and key exons in an additional 28 genes for the presence of sequence variants known to be frequently mutated in hematological malignancies. These genes were chosen because they impact diagnosis, prognosis, or therapy efficacy for both myeloid malignancies (myeloproliferative neoplasms, myelodysplastic syndrome, acute myeloid leukemia) and lymphoid malignancies (acute lymphocytic leukemia, chronic lymphocytic leukemia, non-Hodgkin’s lymphoma, and multiple myeloma).
