This assay utilizes the Affymetrix® CytoScan HD Array. The Chromosomal Microarray Analysis is a targeted, whole genome array that is used in the diagnosis of postnatal genetic disorders. The array contains approximately 1,700,000 oligonucleotide probes and 750,000 SNP probes that detect copy number variations, loss of heterozygosity, uniparental isodisomy, gene amplification, and other chromosomal abnormalities.
Performing Laboratory / Facility
UCLA Medical Center Clinical Laboratory (CHS)
Performing Section
Microarray
Availability
Monday through Friday, 0700-1700
Turnaround Time
3 weeks from receipt of specimen in lab
Methodology
Whole genome oligonucleotide DNA probe capture by array hybridization.
Limitations
This test has been validated by the UCLA Molecular Diagnostics Laboratories, Clinical Microarray Laboratory. The array is designed to detect losses and gains, representing deletions, duplications or amplifications, and the loss of heterozygosity of constitutional disorders. This assay will not detect low level mosaicism, balanced translocations, inversions, or point mutations that may be responsible for the clinical phenotype.
Specimen Type
Whole Blood
Container
Lavender/EDTA
Volume
4ml
Minimum Volume
1mL
Shipping and Handling Instructions
Collect and transport specimen at room temperature. . Store in refrigerator if not delivered to the performing lab on the same day.
Causes for Rejection
Wrong specimen type Frozen or clotted specimens.
Test Information
CPT Codes
81229
Synonyms
aCGH
array-CGH
Microarray
Postnatal Microarray Analysis
SNP
Test Includes
This assay utilizes the Affymetrix® CytoScan HD Array. The Chromosomal Microarray Analysis is a targeted, whole genome array that is used in the diagnosis of postnatal genetic disorders. The array contains approximately 1,700,000 oligonucleotide probes and 750,000 SNP probes that detect copy number variations, loss of heterozygosity, uniparental isodisomy, gene amplification, and other chromosomal abnormalities.
Performing Laboratory / Facility
UCLA Medical Center Clinical Laboratory (CHS)
Performing Section
Microarray
Availability
Monday through Friday, 0700-1700
Turnaround Time
3 weeks from receipt of specimen in lab
Methodology
Whole genome oligonucleotide DNA probe capture by array hybridization.
Limitations
This test has been validated by the UCLA Molecular Diagnostics Laboratories, Clinical Microarray Laboratory. The array is designed to detect losses and gains, representing deletions, duplications or amplifications, and the loss of heterozygosity of constitutional disorders. This assay will not detect low level mosaicism, balanced translocations, inversions, or point mutations that may be responsible for the clinical phenotype.
Specimen Collection and Handling
Specimen Type
Whole Blood
Container
Lavender/EDTA
Volume
4ml
Minimum Volume
1mL
Shipping and Handling Instructions
Collect and transport specimen at room temperature. . Store in refrigerator if not delivered to the performing lab on the same day.
