Aids in the diagnosis of coccidioidomycosis. Includes testing by immunoassay (IgM and IgG), complement fixation, and immunodiffusion. For reflex testing, refer to Coccidioides Antibodies Reflexive Panel, Serum (3001982).
Collect
Serum separator tube (SST).
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP standard transport tube. (Min: 1.2 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
Unacceptable Conditions
Other body fluids. Contaminated, hemolyzed, icteric, or lipemic specimens.
A titer of 1:2 or greater suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative complement fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; anticoccidioidal CF antibody titers in excess of 1:16 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.
Component
Unit Of Measure
Interpretation
Coccidioides Antibody, IgG by ELISA
0.9 IV or less 1.0-1.4 IV 1.5 IV or greater
Negative - No significant level of Coccidioides IgG antibody detected. Equivocal - Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-14 days may be helpful. Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
Coccidioides Antibody, IgM by ELISA
0.9 IV or less 1.0-1.4 IV 1.5 IV or greater
Negative - No significant level of Coccidioides IgM antibody detected. Equivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.
CPT Codes
86635 x4
LOINC
33380-7
90448-2
27009-0
5095-5
Performing Lab
ARUP Laboratories
Collection
Synonyms
Coccidi Ab
Coccidioidomycosis
Precipitin
TP
Valley fever
CF
Coccidioides immitis
Performed
Sun-Sat
Reported
3-6 days
Ordering Recommendations
Aids in the diagnosis of coccidioidomycosis. Includes testing by immunoassay (IgM and IgG), complement fixation, and immunodiffusion. For reflex testing, refer to Coccidioides Antibodies Reflexive Panel, Serum (3001982).
Collect
Serum separator tube (SST).
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP standard transport tube. (Min: 1.2 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.
Unacceptable Conditions
Other body fluids. Contaminated, hemolyzed, icteric, or lipemic specimens.
A titer of 1:2 or greater suggests past or current infection. However, greater than 30 percent of cases with chronic residual pulmonary disease have negative complement fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease; anticoccidioidal CF antibody titers in excess of 1:16 may indicate disseminated infection. CF serology may be used to follow therapy. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.
Component
Unit Of Measure
Interpretation
Coccidioides Antibody, IgG by ELISA
0.9 IV or less 1.0-1.4 IV 1.5 IV or greater
Negative - No significant level of Coccidioides IgG antibody detected. Equivocal - Questionable presence of Coccidioides IgG antibody detected. Repeat testing in 10-14 days may be helpful. Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.
Coccidioides Antibody, IgM by ELISA
0.9 IV or less 1.0-1.4 IV 1.5 IV or greater
Negative - No significant level of Coccidioides IgM antibody detected. Equivocal - Questionable presence of Coccidioides IgM antibody detected. Repeat testing in 10-14 days may be helpful. Positive - Presence of IgM antibody to Coccidioides detected, suggestive of current or recent infection.
Laboratories.