Random or 24-hour urine. Refrigerate 24-hour specimens during collection.
Container
ARUP Amber Transport Tube
Institute
Instructions
Amery, Hudson,
Lakeview,Regions,
Westfields
ARUP Amber Transport Tube (ARUP supply #13654) available online through eSupply using ARUP Connect
HealthPartners
Clinics
Lawson/Warehouse Supply Item: ARUP Amber Transport Tube, Lawson 5008712
Specimen Preparation
Protect from light. Transfer 2 mL aliquot from a random or well-mixed 24-hour collection to ARUP amber transport tubes. (Min: 1.5 mL) Record total volume and collection time interval on transport tube and test request form.
Essential first-line test for suspected acute porphyria in adults. Use in determining metabolic response to IV hematin.
Notes
Appropriate test to rule out acute intermittent porphyria (AIP) and other acute attack types of porphyrias associated with neurologic and/or psychiatric symptoms.
Results for random urine specimens are normalized to creatinine (CRT) concentration and reported as a ratio of amounts (millimoles of PBG/mole of creatinine).
Porphobilinogen (PBG) in a random urine specimen is used to evaluate an attack of acute porphyria. Slight increases in urinary PBG are associated with acute porphyrias other than acute intermittent porphyria (AIP) and may indicate a resolving or treated acute porphyria.
Urinary PBG in excess of two times the upper reference limit is consistent with acute porphyria.
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
CPT Codes
84110
Performing Lab
ARUP Laboratories
Collection
Alias
EPIC-6156; ARUP-0080260
Collect
Random or 24-hour urine. Refrigerate 24-hour specimens during collection.
Container
ARUP Amber Transport Tube
Institute
Instructions
Amery, Hudson,
Lakeview,Regions,
Westfields
ARUP Amber Transport Tube (ARUP supply #13654) available online through eSupply using ARUP Connect
HealthPartners
Clinics
Lawson/Warehouse Supply Item: ARUP Amber Transport Tube, Lawson 5008712
Specimen Preparation
Protect from light. Transfer 2 mL aliquot from a random or well-mixed 24-hour collection to ARUP amber transport tubes. (Min: 1.5 mL) Record total volume and collection time interval on transport tube and test request form.
Essential first-line test for suspected acute porphyria in adults. Use in determining metabolic response to IV hematin.
Notes
Appropriate test to rule out acute intermittent porphyria (AIP) and other acute attack types of porphyrias associated with neurologic and/or psychiatric symptoms.
Results for random urine specimens are normalized to creatinine (CRT) concentration and reported as a ratio of amounts (millimoles of PBG/mole of creatinine).
Porphobilinogen (PBG) in a random urine specimen is used to evaluate an attack of acute porphyria. Slight increases in urinary PBG are associated with acute porphyrias other than acute intermittent porphyria (AIP) and may indicate a resolving or treated acute porphyria.
Urinary PBG in excess of two times the upper reference limit is consistent with acute porphyria.
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Laboratories.